KMID : 0043320150380112049
|
|
Archives of Pharmacal Research 2015 Volume.38 No. 11 p.2049 ~ p.2058
|
|
Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice
|
|
Jeong Se-Jin
Park Jong-Gil Kim Sin-Ai Kweon Hyae-Yon Seo Seung-Woon Na Dae-Seung Lee Dong-Ho Hong Cheol-Yi Na Chun-Soo Dong Mi-Sook Oh Goo-Taeg
|
|
Abstract
|
|
|
Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXR¥á. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.
|
|
KEYWORD
|
|
Rhus verniciflua stokes (RVS), Hyperlipidemia, Bile acid biosynthesis, Liver X receptor ¥á (LXR¥á), Cyp7a1
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|